Wednesday, December 8th, 2021

Protein A Resin Market Size, Share, Growth, Trends, Competitive Landscape, Revenue, Forecast Report 2027

The global Protein A Resin market gathered revenue around USD 1.9 Billion in 2020 and market is set to grow USD 3.2 Billion by the end of 2027 and is estimated to expand at a modest CAGR of 10.9% during the prediction period 2021 to 2027. 

Overview of Protein A Resin Market Study

Protein A Resin market study conducted by Nova One Advisor is intended at helping stakeholders get a comprehensive overview of potential challenges and undiscovered opportunities. The report offers exclusive insights to help companies and their customers to make informed decision to sustain growth through the assessment period.

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Growth Factors:

The growth in this market is mainly driven by the growing demand for disposable pre-packed columns, increasing demand for therapeutic antibodies, and the increasing pharmaceutical R&D spending are expected to drive the growth of this market during the forecast period. However, the high cost of resins is expected to limit the growth of this market.

Protein A Resin Market Dynamics
Drivers: Increasing demand for therapeutic antibodies
Chromatography is an essential step in the purification of monoclonal antibodies (mAbs). Over the past decade, there has been a tremendous increase in the demand for monoclonal antibodies in oncology and several other therapeutic areas, including neurological, autoimmune, and inflammatory disorders. As a result, almost all major pharmaceutical companies are focusing on the R&D of therapeutic antibodies.

In the purification of monoclonal antibodies, anionic impurities, such as nucleic acids and endotoxins, are removed through chromatography. In drug discovery applications, this process consumes a large amount of resins, as the usage is not limited to purification but also includes the study of the ionic interaction of molecules. Impurities such as albumin and transferrin are removed by size-exclusion chromatography (SEC). High levels of purification can be achieved through the use of protein A affinity resins. This is because antibodies selectively bind protein A ligands with the resins. This is expected to drive the demand for protein A resins during the forecast period.

Restrains: High cost of resins
Protein A resins cost around 5-10 times more than other types of resins. Though there are no alternative techniques that can achieve purification levels as high as protein A resins, their high cost makes end users look for alternatives. Some of the techniques that provide acceptable levels of purification include both chromatography and non-chromatography methods. mAb crystallization and precipitation by polyethylene glycol (PEG) precipitation are being explored as alternatives for protein A chromatography.

The impact of this restraining factor is more evident in emerging markets such as APAC and Latin America. However, with the entry of new market players, the cost of protein A resins is expected to come down significantly. The increasing pressure on major market players is expected to result in price reduction, as small market entrants are offering resins at far lower prices, while simultaneously offering comparable product quality.

Opportunities: Increasing number of CMOs and CROs
An increasing number of CMOs and CROs are offering their services to pharmaceutical companies across the globe. This is expected to offer potential growth opportunities to protein A resin manufacturers during the forecast period.

Pharmaceutical companies are increasingly relying on contract manufacturers in various areas of research to fulfill a number of basic needs, such as specialized competencies and cost reduction. The pharmaceutical contract manufacturing industry has experienced robust growth in recent years, and this trend is expected to continue in the coming years. The increasing pressure from several governments to reduce healthcare costs and declining R&D productivity have compelled core pharmaceutical producers to rely on contract manufacturing. Moreover, the rising demand for generic drugs in China and India is a key driver for CMO sales.

The Agarose-based Protein A segment is expected to command the largest market share in 2020.
Based on product, the protein A resin market is segmented into agarose-based protein A, glass/silica-based protein A, and organic polymer-based protein A. In 2020, the agarose-based protein A segment is expected to is expected to command the largest share of the protein A resin market. The large share of this segment can be attributed to the agarose being the most widely used matrix resin for the attachment of ligands that bind proteins.

The antibody purification segment is expected to command the largest market share e in 2020.
Based on application, the protein A resin market is segmented into antibody purification and immunoprecipitation. In 2020, the antibody purification application segment is expected to command the largest share of the protein A resin market. The large share of this segment can primarily be attributed to the increasing demand for monoclonal antibodies for therapeutic as well as research purposes, which has driven the demand for protein A resins used in the downstream processing of these antibodies.

The pharmaceutical and biopharmaceutical companies segment to hold the largest market share in 2020.
Based on end user, the protein A resin market is segmented into pharmaceutical & biopharmaceutical companies, academic research institutes, and other end users. In 2020, the pharmaceutical and biopharmaceutical companies segment is expected to command the largest share of the protein A resin market. The increasing R&D expenditure of pharmaceutical and biopharmaceutical companies is the major factor driving the growth of this end-user segment.

North America is expected to dominate the protein A resin market during the forecast period
Geographically, North America is expected to dominate the global the protein A resin market in 2019, while the Asia Pacific region is expected to register the highest CAGR during the forecast period. The high growth in this region can be attributed to the increased R&D activities, as APAC has emerged as a key pharmaceutical and biopharmaceutical research hub. Considering this, a number of key pharmaceutical and biopharmaceutical companies have set up their research centers in the region. Also, local major players such as Ranbaxy, Dr. Reddy’s, Cipla, Lupin, and Cadila are actively involved in research on biosimilars and generic drugs.

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COVID-19 Impact on Protein A Resin Sales

Businesses today are operating in a dynamic environment. Earlier focus primarily concentrated on keeping pace with changing consumer preferences. COVID-19 outbreak was unprecedented and exposed vulnerabilities of various industries. Pandemic-induces obstacles also were registered in the Protein A Resin market.

Sales plummeted as COVID-19 gradually tightened its noose worldwide. Supply-chain disruptions caused massive losses, while demand took nose-dive as consumers remained indoors with affected countries implementing either partial or complete lockdown.

Gradual recovery however is on the cards with the roll out of vaccinations. Nonetheless, consecutive waves of the virus compelled businesses to stay prepared for the worst. As government and healthcare organizations successfully implement steps to contain the spread of COVID-19, industries have begun operations, albeit at a slow and more cautious pace.

Against this backdrop, Nova one advisor’s study predicts gradual recovery for the Protein A Resin market 2021 onwards. This trend will however continue through the course of the report’s assessment period

Key Players:

This report provides detailed company profiles of the key market players. This research report also highlights the competitive landscape of the Protein A Resin market and ranks noticeable companies as per their occurrence in diverse regions across globe and crucial developments initiated by them in the market space. This research study also tracks and evaluates competitive developments, such as collaborations, partnerships, and agreements, mergers and acquisitions; novel product introductions and developments, promotion strategies and Research and Development (R&D) activities in the marketplace. The competitive profiling of these players includes business and financial overview, gross margin, production, sales, and recent developments which can aid in assessing competition in the market.

Some of the prominent players in the Protein A Resin market include:

GE Healthcare (US), Merck Millipore (Germany), Repligen Corporation (US), Thermo Fisher Scientific (US), Tosoh Bioscience (Japan), Purolite Corporation (US), Novasep Holding SAS (France), Agilent Technologies (US), GenScript Biotech Corporation (China), PerkinElmer (US), Bio-Rad Laboratories (US), Orochem (US), Kaneka Corporation (Japan), Abcam (UK), Agarose Bead Technologies (US), Avantor (US), JSR Life Sciences (US), Bio-Works Technologies (Sweden), Amikozen Co. Ltd. (US), and Takara Bio Inc. (Japan).

Unravelling the Critical Segments

This research report offers market revenue, sales volume, production assessment and prognoses by classifying it on the basis of various aspects including product type, application/end-user, and region. Further, this research study investigates market size, production, consumption and its development trends at global, regional, and country level for period 2017 to 2027 and covers subsequent region in its scope:

By Product

  • Agarose-based Protein A
  • Glass/Silica-based Protein A
  • Organic Polymer-based Protein A

By Type

  • Recombinant Protein A
  • Natural Protein A

By Application

  • Antibody Purification
  • Immunoprecipitation

By End-User

  • Pharmaceutical & Biopharmaceutical Companies
  • Academic Research Institutes
  • Other End Users

Why Buy this Report?

The purpose of Nova one advisor’s Protein A Resin market study is to provide stakeholders with a detailed picture of potential barriers and untapped opportunities. The report contains exclusive information to assist businesses in making informed decisions about how to maintain growth throughout the assessment period.

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