Saturday, December 4th, 2021

Aluda Pharmaceuticals announces results for a novel anti-COVID agent with both anti-viral and anti-inflammatory actions

MENLO PARK, Calif., Oct. 13, 2021 /PRNewswire/ — Aluda Pharmaceuticals announced the publication of “A Vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases” in the peer reviewed journal mBio describing multiple actions of Aluda’s clinical candidate ALD-R491 in viral infection, lung injury and fibrosis, hyperinflammation and, more generally, autoimmune disease.

The paper presents results of multiple studies, including Aluda’s NIH sponsored SARS-CoV-2 study, in which aged mice were used and drug was administered after full-blown infection (both harder than standard protocol). The treated mice showed improved general condition and reduced lung damage, both outcomes also seen in separate ALD-R491 studies of lung injury-related fibrosis. These therapeutic effects are attributed to the ability of ALD-R491 to control both viral infection and hyperinflammation.

Unlike drugs that target the spike or other viral proteins to block SARS-CoV-2 infection, ALD-R491 targets a cellular protein to block the virus’s entry, movement within, and exit from the cell. In a cell-based assay, ALD-R491 protected almost all cells (>90%) from becoming infected by virus through SARS-CoV2 spike protein and its human ACE2 receptor. In addition, ALD-R491 enhanced the pathogen-killing ability of macrophages, which could facilitate the viral clearance, and therefore avoid the escalation of hyperinflammation and the persistence of disease (long COVID). Importantly, all of these actions cannot be evaded by the virus through mutations, because ALD-R491’s target protein in the host cell remains the same regardless of COVID variant.

ALD-491 also has an immune balancing effect which fights hyperinflammation through a “direct” activation of regulatory T cells. This action addresses the continuing unmet need of lowering COVID’s main cause of death and damage.

Since 95% of COVID cases are not severe and patients can recover by themselves, the value of an anti-COVID therapeutic drug is to prevent the remaining 5% from becoming severe or to treat them if they do. Anti-viral drugs can play a role in preventing, but not treating, severe disease because hyperinflammation, not the virus itself, drives disease progression and severity. Unfortunately, most antiviral drugs are not mechanistically safe enough for this prevention role, as seen with the risk of mutagenicity of Molnupiravir (positive Ames test for genotoxicity), which could impose substantive risks but confer no benefits to 95% of COVID patients.

ALD-R491 has anti-viral and anti-inflammatory actions that offer the potential to both prevent progression and resolve severe COVID. Its oral administration and excellent safety profile would make it suitable for wide use in patients, in or out of the hospital, at any stage and under any health condition (regular, fragile, and elderly). In addition, its ability to reduce lung fibrosis would address an important unmet need in COVID.

Dr. Ruihuan Chen, CEO of Aluda said, “Our approach is a perfect fit to COVID, because it addresses the multifaceted pathology of the disease. Vimentin targeting lets the cell block the virus in multiple ways that cannot be bypassed by viral mutations, and makes the immune system eliminate the virus but not overreact to it. Our findings have direct relevance to treating both infectious and non-infectious conditions that share similar pathological processes.”

Steven Projan, Ph.D., an editor of mBio, noted, “Host-directed mechanisms have been underappreciated and undervalued in the fight on COVID and we feel it is important to share these findings with the community as we see a rise of variants. This program is exciting for its unique target that addresses both virus and inflammation, with actions that will be complementary to our existing set of spike protein-directed drugs.”

About ALD-R491

ALD-R491 specifically targets vimentin, an intermediate filament protein that plays an essential role in the progression of various diseases, from autoimmune to fibrosis and cancer. As the first-in-class vimentin-binding small molecule, ALD-R491 has shown broad efficacy in many disease models, and an excellent safety profile in the studies required for IND filing.

About Aluda

Aluda discovers and develops novel small molecule drugs for unmet medical needs. Programs include both new and previously explored drug targets in the areas of inflammation, autoimmune, fibrosis and oncology. For more see www.aludapharm.com.

https://www.chronline.com/stories/freelive-new-mexico-state-vs-alabama-liveonline-football-free-november-13-2021,278271
https://www.chronline.com/stories/ncaaflive-alabama-vs-new-mexico-state-live-college-football-november-13-2021,278272
https://www.chronline.com/stories/freelive-michigan-vs-penn-state-liveonline-football-free-november-13-2021,278273
https://www.chronline.com/stories/ncaaflive-penn-state-vs-michigan-live-college-football-november-13-2021,278274
http://www.chronline.com/stories/freelive-oklahoma-vs-baylor-liveonline-football-free-november-13-2021,278277
https://www.chronline.com/stories/ncaaflive-baylor-vs-oklahoma-live-college-football-november-13-2021,278279
https://www.chronline.com/stories/freelive-mississippi-state-vs-auburn-liveonline-football-free-november-13-2021,278281
https://www.chronline.com/stories/ncaaflive-auburn-vs-mississippi-state-live-college-football-november-13-2021,278282
https://www.chronline.com/stories/freelive-northwestern-vs-wisconsin-liveonline-football-free-november-13-2021,278284
http://www.chronline.com/stories/ncaaflive-wisconsin-vs-northwestern-live-college-football-november-13-2021,278285
https://www.chronline.com/stories/freelive-samford-vs-florida-liveonline-football-free-november-13-2021,278291
http://www.chronline.com/stories/ncaaflive-florida-vs-samford-live-college-football-november-13-2021,278293
https://www.chronline.com/stories/freelive-clemson-vs-uconn-liveonline-football-free-november-13-2021,278295
https://www.chronline.com/stories/ncaaflive-uconn-vs-clemson-live-college-football-november-13-2021,278297
https://www.chronline.com/stories/freelive-syracuse-vs-louisville-liveonline-football-free-november-13-2021,278299
http://www.chronline.com/stories/ncaaflive-louisville-vs-syracuse-live-college-football-november-13-2021,278301
http://www.chronline.com/stories/freelive-rutgers-vs-indiana-liveonline-football-free-november-13-2021,278303
https://www.chronline.com/stories/ncaaflive-maine-vs-umass-live-college-football-november-13-2021,278306
https://www.chronline.com/stories/freelive-west-virginia-vs-kansas-state-liveonline-football-free-november-13-2021,278308
http://www.chronline.com/stories/ncaaflive-kansas-state-vs-west-virginia-live-college-football-november-13-2021,278310
https://www.chronline.com/stories/freelive-ucf-vs-smu-liveonline-football-free-november-13-2021,278311
https://www.chronline.com/stories/ncaaflive-east-carolina-vs-memphis-live-college-football-november-13-2021,278312
http://www.chronline.com/stories/freelive-houston-vs-temple-liveonline-football-free-november-13-2021,278313
https://www.chronline.com/stories/ncaaflive-bucknell-vs-army-live-college-football-november-13-2021,278314
https://www.chronline.com/stories/ncaaflive-arizona-vs-utah-live-college-football-november-13-2021,278316
https://www.chronline.com/stories/freelive-utah-vs-arizona-liveonline-football-free-november-13-2021,278315
https://www.chronline.com/stories/rice-vs-western-kentucky-live-college-football-2021,278318
https://www.chronline.com/stories/freelive-western-kentucky-vs-rice-liveonline-football-free-november-13-2021,278317
https://www.chronline.com/stories/coastal-carolina-vs-georgia-state-live-college-football-2021,278320
https://www.chronline.com/stories/freelive-georgia-state-vs-coastal-carolina-liveonline-football-free-november-13-2021,278319
https://www.chronline.com/stories/freelive-south-alabama-vs-appalachian-state-liveonline-football-free-november-13-2021,278321
https://www.chronline.com/stories/appalachian-state-vs-south-alabama-live-college-football-2021,278322
https://www.chronline.com/stories/freelive-georgia-southern-vs-texas-state-liveonline-football-free-november-13-2021,278323
https://www.chronline.com/stories/texas-state-vs-georgia-southern-live-college-football-2021,278324
https://www.chronline.com/stories/freelive-georgia-vs-tennessee-liveonline-football-free-november-13-2021,278325
https://www.chronline.com/stories/tennessee-vs-georgia-live-college-football-2021,278326
https://www.chronline.com/stories/freelive-purdue-vs-ohio-state-liveonline-football-free-november-13-2021,278327
http://www.chronline.com/stories/ohio-state-vs-purdue-live-college-football-2021,278328
https://www.chronline.com/stories/freelive-minnesota-vs-iowa-liveonline-football-free-november-13-2021,278329
https://www.chronline.com/stories/iowa-vs-minnesota-live-college-football-2021,278330
https://www.chronline.com/stories/freelive-southern-miss-vs-utsa-liveonline-football-free-november-13-2021,278331
http://www.chronline.com/stories/utsa-vs-southern-miss-live-college-football-2021,278332
https://www.chronline.com/stories/freelive-charlotte-vs-louisiana-tech-liveonline-football-free-november-13-2021,278333
http://www.chronline.com/stories/ncaaflive-louisiana-tech-vs-charlotte-live-college-football-november-13-2021,278334
https://www.chronline.com/stories/freelive-florida-international-vs-middle-tennessee-liveonline-football-free-november-13,278335
https://www.chronline.com/stories/middle-tennessee-vs-florida-international-live-college-football-2021,278336
https://www.chronline.com/stories/freelive-florida-atlantic-vs-old-dominion-liveonline-football-free-november-13-2021,278337
https://www.chronline.com/stories/old-dominion-vs-florida-atlantic-live-college-football-2021,278338
https://www.chronline.com/stories/uab-vs-marshall-live-college-football-2021,278339
https://www.chronline.com/stories/freelive-miami-vs-florida-state-liveonline-football-free-november-13-2021,278340
http://www.chronline.com/stories/florida-state-vs-miami-live-college-football-2021,278341
https://www.chronline.com/stories/freelive-boston-college-vs-georgia-tech-liveonline-football-free-november-13-2021,278342
https://www.chronline.com/stories/georgia-tech-vs-boston-college-live-college-football-2021,278343
https://www.chronline.com/stories/freelive-duke-vs-virginia-tech-liveonline-football-free-november-13-2021,278344
https://www.chronline.com/stories/virginia-tech-vs-duke-live-college-football-2021,278345
https://www.chronline.com/stories/freelive-iowa-state-vs-texas-tech-liveonline-football-free-november-13-2021,278346
https://www.chronline.com/stories/texas-tech-vs-iowa-state-live-college-football-2021,278347
https://www.chronline.com/stories/freelive-louisiana-vs-troy-liveonline-football-free-november-13-2021,278350
https://www.chronline.com/stories/troy-vs-louisiana-live-college-football-2021,278351
https://www.chronline.com/stories/freelive-maryland-vs-michigan-state-liveonline-football-free-november-13-2021,278352
http://www.chronline.com/stories/michigan-state-vs-maryland-live-college-football-2021,278353
https://www.chronline.com/stories/michigan-state-vs-maryland-live-college-football-2021,278353
https://www.chronline.com/stories/freelive-south-carolina-vs-missouri-liveonline-football-free-november-13-2021,278355
https://www.chronline.com/stories/missouri-vs-south-carolina-live-college-football-2021,278357
https://www.chronline.com/stories/freelive-utep-vs-north-texas-liveonline-football-free-november-13-2021,278358
http://www.chronline.com/stories/north-texas-vs-utep-live-college-football-2021,278359
https://www.chronline.com/stories/freelive-tulsa-vs-tulane-liveonline-football-free-november-13-2021,278361
https://www.chronline.com/stories/tulane-vs-tulsa-live-college-football-2021,278362
https://www.chronline.com/stories/freelive-hawaii-vs-unlv-liveonline-football-free-november-13-2021,278364
https://www.chronline.com/stories/unlv-vs-hawaii-live-college-football-2021,278365
https://blog.goo.ne.jp/saykat0/e/673edd709644c13edc549c8d24913d02
https://blog.goo.ne.jp/saykat0/e/b5fb09a90669246b44d267a849ff8aac

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.